Susceptibility and immunity to helminth parasites
نویسندگان
چکیده
Parasitic helminth infection remains a global health problem, whilst the ability of worms to manipulate and dampen the host immune system is attracting interest in the fields of allergy and autoimmunity. Much progress has been made in the last two years in determining the cells and cytokines involved in induction of Type 2 immunity, which is generally protective against helminth infection. Innate cells respond to 'alarmin' cytokines (IL-25, IL-33, TSLP) by producing IL-4, IL-5 and IL-13, and this sets the stage for a more potent subsequent adaptive Th2 response. CD4+ Th2 cells then drive a suite of type 2 anti-parasite mechanisms, including class-switched antibodies, activated leukocytes and innate defence molecules; the concerted effects of these multiple pathways disable, degrade and dislodge parasites, leading to their destruction or expulsion.
منابع مشابه
New records about helminth parasites of the marsh frog, Rana ridibunda ridibunda (Anura: Ranidae) from the north of Iran
A field trials were conducted to assess the helminth parasites of 12 marsh frogs (Rana ridibunda ridibunda) in the Anzali, Astara and Aghbaba regions in the north of Iran in May 1994. Experimental results showed that 83.8% of the Anzali marsh frogs were infected by one or two kinds of metacercarian cysts of digenetic trematodes. The helminth parasites were included Skrjabinoeces breviansa, S. s...
متن کاملAuthor's personal copy Susceptibility and immunity to helminth parasites
Parasitic helminth infection remains a global health problem, whilst the ability of worms to manipulate and dampen the host immune system is attracting interest in the fields of allergy and autoimmunity. Much progress has been made in the last two years in determining the cells and cytokines involved in induction of Type 2 immunity, which is generally protective against helminth infection. Inna...
متن کاملNew records about helminth parasites of the marsh frog, Rana ridibunda ridibunda (Anura: Ranidae) from the north of Iran
A field trials were conducted to assess the helminth parasites of 12 marsh frogs (Rana ridibunda ridibunda) in the Anzali, Astara and Aghbaba regions in the north of Iran in May 1994. Experimental results showed that 83.8% of the Anzali marsh frogs were infected by one or two kinds of metacercarian cysts of digenetic trematodes. The helminth parasites were included Skrjabinoeces breviansa, S. s...
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